Endocrine Abstracts

Type 1 diabetes (T1D) is a chronic disease of childhood that also presents in adults, resulting from the destruction of insulin-producing β-cells by auto-reactive T cells that have escaped central and peripheral immune tolerance. It is now well established that T1D is characterised by a wide heterogeneity especially in terms of age at onset, representing a major barrier for both pathogenesis and translational efforts aimed to develop novel therapeutics approach. This conc...

Background: Technological advances in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) should aim to improve glucose control and quality of life in patients diagnosed type 1 diabetes (T1D).Aim: The aim of our study was to compare different CGM and CSII devices on these targets.Methods: Sixty-nine T1D patients (mean age 39±12; 31 males) were recruited. 36 were on multiple daily insulin inj...

Background: carbohydrate counting is often performed inaccurately by patients with type 1 diabetes (T1D). We hypothesized that mobile App ‘Dietrometro’, that estimates CHO content of food figures, would ameliorate glucose control.Aim: To study the effect of ‘Dietometro’ on glucose control.Methods: 54 T1D subjects (aged 18-60 years, 26 males), on multiple daily injections (n=23) or continuous subcutaneou...

Introduction: The American Diabetes Association (ADA) produced a triple composite outcome that summarizes the therapeutic targets of the three most prevalent complications of obesity: type 2 diabetes (T2D), hypertension and dyslipidemia (HbA1c <7.0%; LDL cholesterol<100 mg/dl and systolic blood pressure <130 mmHg). The present study primarily investigates the difference between VSG and RYGB in achieving the composite target one year after the surgery. The secondary...

Introduction: Primary hyperparathyroidism (PHPT) after roux-en-Y gastric bypass (RYGB) is poorly described. The diagnosis can be difficult as secondary hyperparathyroidism(SHPT) commonly occurs in patients after RYGB due to calcium hypoabsorption and vitamin D deficiency.Observation: We present the case of a 50-year-old female with a history of normocalcemic hyperparathyroidism and nephrolithiasis. In 2005 the patient had undergone RYGB. During the first...

Overweight and obese subjects often suffer from hypoglycaemic symptoms due to hyperinsulinemia. This increases subjects’ need to eat excessive amount of food enriched in sugar causing rebound hyperglycaemia which in turn stimulates endogenous insulin release perpetuating a vicious circle that limits weight loss under diet restriction programme. Two previous studies showed that administration of Glucose RapidSpray™ (GRS) in quantity of ~ 0.5 g increases blood glucose ...

Reg and Reg-related genes are members of a multifunctional family. Under physiological conditions Reg protein is not expressed in pancreatic beta cells, although the Reg protein receptor is expressed. When islets are damaged, the expression of Reg gene is increased in the islets of Langherans. In type 1 diabetes (T1D), insulin secretion may be still detectable in some subjects with long-standing disease indicating the existence of a small population of surviving beta cells or ...

Hypoglycaemia continues to be a difficult condition to treat especially in infants and young children who cannot administer treatment themselves. Administering the correct dose of sugar is difficult for several reasons: the child may not want to intake food and it may be difficult to force the child to chew or swallow, it is difficult to identify the quantity of sugar necessary to reach optimal glucose levels. If too much sugar is administered, high levels of blood glucose may...

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...

BackgroundRadiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs). We compared the efficacy and safety of both thermal ablation treatments at the 12-month follow-up in patients with solid or predominantly solid BNTN.MethodsThis 12-month, single-use, randomized open-label parallel trial c...